Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats
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منابع مشابه
Dibutyl Phthalate Rather than Monobutyl Phthalate Facilitates Contact Hypersensitivity to Fluorescein Isothiocyanate in a Mouse Model.
Dibutyl phthalate (DBP) is a plasticizer used for many consumer products including cosmetics. Potential health concerns regarding DBP include reproductive and developmental toxicity, endocrine disruption and neurotoxicity. DBP is a high priority chemical as to reduction of exposure of children to it. Through reproductive toxicity studies, monobutyl phthalate (MBP) has been proposed to be the ac...
متن کاملMitochondrial effect of orally administered dibutyl phthalate in rats.
activity in liver homogenate from di-2-ethylhexyl phthalate (DEHP)-treated rats. Ohyama9) showed in vitro that PAEs inhibited mitochondrial respiration, with di-n-butyl phthalte (DBP) showing the strongest effect, and he concluded that PAEs were inhibitors of electron and energy transfer systems but not uncouplers. Takahashi10) also found inhibitory effects of PAEs on respiration in vitro and a...
متن کاملCumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.
Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract malformations in rats and rabbits. In the fetal male rat, these two phthalate esters decrease testosterone (T) production and insulin-like peptide 3 (insl3) gene expression, a hormone critical for gubernacular ligament development. We hypothesized t...
متن کاملInfluence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate.
What limited evidence there is indicates that the formulation in which a chemical allergen is encountered on the skin can have a marked impact upon the induction of cutaneous immune responses and the subsequent development of contact sensitization. The purpose of the present investigations was to examine further this phenomenon by analysis of the influence of dibutyl phthalate (DBP) on dermal s...
متن کاملThe in vitro serum protein-binding characteristics of bis-(2-ethylhexyl) phthalate and its principal metabolite, mono-(2-ethylhexyl) phthalate.
The metabolism and toxicity of the ubiquitous plasticizer, bis-(2-ethylhexyl) phthalate (DEHP), and its principal metabolite, mono-(2-ethylhexyl) phthalate (MEHP), have been extensively investigated. In an attempt to understand their disposition in man, we studied the in vitro serum protein-binding characteristics of these compounds, using ultracentrifugation and agarose gel electrophoresis. Th...
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ژورنال
عنوان ژورنال: Congenital Anomalies
سال: 2002
ISSN: 0914-3505,1741-4520
DOI: 10.1111/j.1741-4520.2002.tb00896.x